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pentobarbital will lower the extent or effect of prednisone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.pentobarbital increases toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. CYP3A4 inducers may well enhance the metabolism of ifosfamide to its active alkylating m

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